Allergic rhinitis, seasonal: Olopatadine 665 mcg per spray:
Children 6 to <12 years: Intranasal: 1 spray per nostril twice daily.
Children ≥12 years and Adolescents: Intranasal: 2 sprays per nostril twice daily.
Children ≥6 years and Adolescents:
Mild, moderate, or severe impairment: No dosage adjustment necessary.
Children ≥6 years and Adolescents: No dosage adjustment necessary as metabolism of olopatadine is only a minor route of elimination.
(For additional information see "Olopatadine (nasal): Drug information")
Allergic rhinitis, seasonal: Intranasal: 2 sprays into each nostril twice daily.
Nonallergic rhinitis (off-label use): Intranasal: 2 sprays into each nostril twice daily (Ref).
No dosage adjustment necessary.
No dosage adjustment necessary.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
>10%:
Central nervous system: Bitter taste (13%; children: 1%)
Respiratory: Epistaxis (3% to 25%)
1% to 10%:
Central nervous system: Depression (2%), drowsiness (1%), fatigue (1%)
Dermatologic: Skin rash (children: 1%)
Endocrine & metabolic: Weight gain (1%)
Gastrointestinal: Xerostomia (1%)
Genitourinary: Urinary tract infection (1%)
Infection: Influenza (1%)
Neuromuscular & skeletal: Increased creatine phosphokinase (1%)
Respiratory: Nasal mucosa ulcer (9% to 10%), upper respiratory tract infection (children: 3%), pharyngolaryngeal pain (2%), post nasal drip (2%), cough (1%), throat irritation (1%)
<1%, postmarketing, and/or case reports: Altered sense of smell, anosmia, dizziness, dysgeusia, nasal discomfort, oropharyngeal pain
There are no contraindications listed in the manufacturer's labeling.
Concerns related to adverse effects:
• CNS depression: May cause drowsiness in some patients; instruct patient to use caution when driving or operating machinery. Effects may be additive with CNS depressants and/or ethanol.
• Nasal ulcerations: Periodically examine nasal mucosa for ulceration and consider discontinuing if ulceration occurs.
Patanase 30.5 g bottles contain 240 sprays.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Solution, Nasal:
Patanase: 0.6% (30.5 g [DSC]) [contains benzalkonium chloride, edetate (edta) disodium]
Generic: 0.6% (30.5 g)
Yes
Solution (Olopatadine HCl Nasal)
0.6% (per gram): $3.54 - $10.24
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Intranasal: For intranasal use only; do not spray in eyes. Before initial use of the nasal spray, the delivery system should be primed with 5 sprays or until a fine mist appears. If >7 days have elapsed since last use, the delivery system should be reprimed with 2 sprays or until a fine mist appears. Blow nose to clear nostrils. Keep head tilted downward when spraying. Insert applicator into nostril, keeping bottle upright, and close off the other nostril. Aim nasal applicator to the cheek side of the nose, away from the center of nose. Breathe in through nose. While inhaling, press pump to release spray. Breathe out through mouth. Alternate sprays between nostrils. Do not tip head back or blow nose right after use; may cause bitter taste in mouth. After each use, wipe the spray tip with a clean tissue or cloth. Discard after 240 sprays (enough for 30 days of dosing) have been used, even if bottle is not completely empty.
Intranasal: For intranasal use only; do not spray in eyes. Before initial use of the nasal spray, the delivery system should be primed with 5 sprays or until a fine mist appears. If ≥7 days have elapsed since last use, the delivery system should be reprimed with 2 sprays. Blow nose to clear nostrils. Keep head tilted downward when spraying. Insert applicator into nostril, keeping bottle upright, and close off the other nostril. Breathe in through nose. While inhaling, press pump to release spray. Alternate sprays between nostrils. After each use, wipe the spray tip with a clean tissue or cloth. Discard after 240 sprays (enough for 30 days of dosing) have been used, even if bottle is not completely empty.
Store at 4°C to 25°C (39°F to 77°F). Discard after 240 sprays (enough for 30 days of dosing) have been used.
Treatment of the symptoms of seasonal allergic rhinitis (FDA approved in ages ≥6 years and adults).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program
CNS Depressants: Olopatadine (Nasal) may enhance the CNS depressant effect of CNS Depressants. Risk X: Avoid combination
Other agents may be preferred for the treatment of allergic rhinitis during pregnancy (BSACI [Scadding 2017]).
Monitor for adverse nasal effects (eg, nasal septal perforation, nasal ulceration, irritation, epistaxis).
Selective histamine H1-antagonist; inhibits release of histamine from mast cells.
Onset of action: 30 minutes in seasonal allergy patients.
Protein binding: ~55% (primarily albumin).
Metabolism: Not extensively metabolized.
Bioavailability: 57%.
Half-life elimination: 8 to 12 hours.
Time to peak, serum: 15 minutes to 2 hours.
Excretion: Urine (~70%, mostly as unchanged drug); feces (17%).
Sex: Cmax and AUC0 to12 were 40% and 27% higher, respectively, in females compared with males (intranasal).
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