ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; CRP: C-reactive protein.
* If dexamethasone is unavailable, other glucocorticoids at equivalent doses are reasonable alternatives.
¶ For those who are stably on minimal supplemental oxygen (eg, 1 to 2 L/min), it is reasonable to forgo dexamethasone and use remdesivir alone, particularly in patients who are immunocompromised and within 10 days of illness onset.
Δ The clinical benefit of remdesivir is uncertain in patients who need support beyond low-flow oxygen, but it is reasonable to use it in those on high-flow or noninvasive ventilation, particularly if they are immunocompromised and receiving immunomodulatory agents for COVID-19.
◊ Tocilizumab and baricitinib should be used with caution in immunocompromised patients, among whom the safety of further immune modulation with such agents is uncertain.Do you want to add Medilib to your home screen?