Age <28 days |
Ill appearance |
Rectal temperature ≥38.5°C (101.3°F; infants 22 to 60 days old only)¶ |
Prematurity (gestational age <37 weeks) |
Received antibiotics within:
|
Comorbidities or chronic illness (any one of the following):
|
Maternal risk for early-onset sepsis (neonates <14 days only, any one of the following):
|
Focal infection◊ |
* Invasive bacterial illness (IBI) primarily refers to bacteremia and meningitis.
¶ For well-appearing neonates 22 to 28 days old and infants 29 to 60 days old in settings where procalcitonin measurements are not readily available, a temperature ≥38.6°C may also be used as an inflammatory marker that raises the risk of IBI along with absolute neutrophil count, or C-reactive protein (refer to UpToDate content on evaluation and management of the febrile neonate and the febrile infant 29 to 60 days of age).
Δ Examples include home ventilator, home oxygen, or total parenteral nutrition.
◊ Focal infections associated with an increased risk of IBI in febrile young infants include cellulitis, abscess, pneumonia, osteomyelitis, bacterial arthritis, and omphalitis.Do you want to add Medilib to your home screen?