Type of prophylaxis | When to initiate | Available agents¶ | Duration |
Postexposure prophylaxis | As soon as possible within 48 hours of exposure |
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Pre-exposure prophylaxis awaiting response to influenza vaccine | Onset of influenza activity in the communityΔ |
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Other indications for pre-exposure prophylaxis | Onset of influenza activity in the communityΔ |
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* Chemoprophylaxis is not routinely recommended. Chemoprophylaxis of select children ≥3 months of age who are at very high risk of severe or complicated influenza (eg, those who are severely immunocompromised) or their close contacts is an alternative to early initiation of antiviral therapy. Refer to related UpToDate content for dosing information.
¶ Laninamivir is another inhaled neuraminidase inhibitor that is available for prophylaxis in Japan.
Δ Information about influenza activity at the national, regional, and state level is available from the United States Centers for Disease Control and Prevention (FluView interactive) and the World Health Organization (FluNet). Local hospital or clinic laboratories may also collect information about influenza activity in a specific geographic area.Do you want to add Medilib to your home screen?