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Revised International Staging System for multiple myeloma

Revised International Staging System for multiple myeloma
Stage I Stage II Stage III
All of the following:
  • B2M <3.5 mg/L
  • Serum albumin ≥3.5 g/dL
  • Normal LDH
  • No del(17p), t(4;14), or t(14;16) by FISH
 Neither stage I nor stage III Both of the following:
  • B2M ≥5.5 mg/L
  • Elevated LDH and/or del(17p), t(4;14), or t(14;16) by FISH
B2M: beta-2 microglobulin; LDH: lactate dehydrogenase; FISH: fluorescence in situ hybridization.
Adapted from: Palumbo A, Avet-Loiseau H, Oliva S, et al. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. J Clin Oncol 2015; 33:2863.
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