Cutaneous candidiasis (including diaper dermatitis): Limited data available:
Infants, Children, and Adolescents: Cream: Topical: Apply sufficient amount to cover affected area twice daily for 2 weeks (Ref).
Tinea corporis, tinea cruris, and tinea versicolor (pityriasis versicolor) (smaller lesions):
Children and Adolescents: Limited data available: Cream: Topical: Apply sufficient amount to cover affected area once daily for 4 weeks (Ref).
Tinea pedis:
Cream: Children and Adolescents: Limited data available: Topical: Apply sufficient amount to cover affected area once daily for 4 weeks (Ref).
Foam: Children ≥12 years and Adolescents: Topical: Apply sufficient amount to cover affected area once daily for 4 weeks.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
(For additional information see "Econazole: Drug information")
Cutaneous candidiasis: Topical: Cream 1%: Apply sufficient quantity twice daily (morning and evening) for 2 weeks.
Tinea infections:
Tinea corporis/tinea cruris: Topical: Cream 1%: Apply to affected and surrounding area(s) once daily until clinical resolution, typically 1 to 3 weeks (Ref).
Tinea pedis (labeled use)/tinea manuum (off-label use): Topical: Cream 1%, foam 1%: Apply to affected and surrounding area(s) once daily until 1 week after clinical resolution, typically for 4 weeks total (Ref).
Tinea versicolor (pityriasis versicolor): Topical: Cream 1%: Apply to affected area(s) and immediate surrounding skin once daily for 2 weeks (Ref).
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
1% to 10%: Dermatologic: Burning sensation of skin (3%), erythema (3%), pruritus (3%), stinging of the skin (3%)
<1%, postmarketing, and/or case reports: Application site reaction, pruritic rash
Cream: Hypersensitivity to econazole or any component of the formulation.
Foam: There are no contraindications listed in the manufacturer's labeling.
Concerns related to adverse effects:
• Irritation: Discontinue if sensitivity or irritation occurs.
Dosage form specific issues:
• Foam: Avoid heat, flame, and smoking during and immediately following application; topical foam is flammable.
Other warnings/precautions:
• Appropriate use: For topical use only; avoid contact with eyes, mouth, nose, or other mucous membranes
Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP 1997; Shehab 2009).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Cream, External, as nitrate:
Generic: 1% (15 g, 30 g, 85 g)
Foam, External, as nitrate:
Ecoza: 1% (70 g) [contains propylene glycol, trolamine (triethanolamine)]
Kit, External, as nitrate:
Econasil: 1% [DSC] [contains benzoic acid]
Zolpak: 1% [DSC] [contains benzoic acid]
May be product dependent
Cream (Econazole Nitrate External)
1% (per gram): $2.00 - $7.25
Foam (Ecoza External)
1% (per gram): $10.47
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: For external use only. Not for oral, ophthalmic, or vaginal use. Avoid contact with the eyes. Shake foam canister for ~5 seconds before application.
Topical: For external use only. Not for oral, ophthalmic, or vaginal use. Avoid contact with the eyes.
Cream: Store below 30°C (86°F).
Foam: Store at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F). Do not expose to heat and/or store at temperatures >49°C (120°F) even when the container is empty. Do not store in direct sunlight. Do not refrigerate or freeze.
Cream: Topical treatment of tinea pedis, tinea cruris, tinea corporis, tinea versicolor (pityriasis versicolor), and cutaneous candidiasis (FDA approved in adults).
Foam: Topical treatment of interdigital tinea pedis (FDA approved in ages ≥12 years and adults).
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program
Vitamin K Antagonists (eg, warfarin): Econazole may increase the serum concentration of Vitamin K Antagonists. Risk C: Monitor therapy
Information related to econazole use in pregnancy is primarily from use for other indications and route of administration. Until more data are available, it is suggested to avoid use in the first trimester and apply sparingly during the second and third trimesters if needed for topical fungal infections (Patel 2017).
Reassess diagnosis if no clinical improvement after 2 weeks.
Alters fungal cell wall membrane permeability; may interfere with RNA and protein synthesis, and lipid metabolism
Absorption: Cream: <10%
Metabolism: Cream: Hepatic to more than 20 metabolites
Time to peak: Foam: 6.8 ± 5.1 hours
Excretion: Cream: Urine (<1%); feces (<1%)
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