Red blood cell (RBC) enzyme map

Enzymes implicated in clinical disease are depicted in yellow. Refer to UpToDate for details of enzymatic pathways and related clinical disorders.

RBC: red blood cell; ATP: adenosine triphosphate; NAD: nicotine adenine dinucleotide.

Adapted from: Koralkova P, van Solinge WW, van Wijk R. Rare hereditary red blood cell enzymopathies associated with hemolytic anemia - pathophysiology, clinical aspects, and laboratory diagnosis. Int J Lab Hematol 2014; 36:388.