Drug | Preparations | Daily dose (administered as a single dose) |
Isoniazid* | Oral:
| 300 mg |
Rifapentine | Oral:
| 1.2 g |
Moxifloxacin | Oral:
| 400 mg |
Pyrazinamide | Oral:
| Dosing based on patient weight:¶
|
IM: intramuscular; IV: intravenous; CrCl: creatinine clearance.
* Pyridoxine (vitamin B6) 25 to 50 mg/day is given with isoniazid to individuals at risk for neuropathy (eg, pregnant women, individuals with HIV infection, diabetes, alcoholism, malnutrition, chronic renal failure, or advanced age). For patients with peripheral neuropathy, experts recommend increasing pyridoxine dose to 100 mg/day.
¶ Based on actual body weight[1]. Some experts dose based on estimated lean body weight[2]. A calculator for estimating lean body weight is available separately in UpToDate.Do you want to add Medilib to your home screen?