Clinical stage | ||||
When primary tumor (cT) status is... | And lymph node (cN) status is... | And distant metastasis (M) status is... | And heritable trait (H) status is... | Then the clinical stage is... |
cT1, cT2, cT3 | cN0 | cM0 | Any | Stage I |
cT4a | cN0 | cM0 | Any | Stage II |
cTb | cN0 | cM0 | Any | Stage III |
Any | cN1 | cM0 | Any | Stage III |
Any | Any | cM1 or pM1 | Any | Stage IV |
Definition of primary tumor (cT) – Based on the most advanced eye | ||||
cTX | Unknown evidence of intraocular tumor | |||
cT0 | No evidence of intraocular tumor | |||
cT1 | Intraocular tumor(s) with subretinal fluid ≤5 mm from the base of any tumor:
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cT2 | Intraocular tumor(s) with retinal detachment, vitreous seeding or subretinal seeding:
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cT3 | Advanced intraocular tumor(s):
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cT4 | Extraocular tumor(s) involving the orbit, including the optic nerve:
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Definition of regional lymph nodes (cN) | ||||
cNX | Regional lymph nodes cannot be assessed | |||
cN0 | No regional lymph nodes involvement | |||
cN1 | Evidence of preauricular, submandibular, and cervical lymph node involvement | |||
Definition of distant metastasis (M) | ||||
cM0 | No signs or symptoms of intracranial or distant metastasis | |||
cM1 | Distant metastasis without microscopic confirmation:
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pM1 | Distant metastasis with microscopic confirmation:
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Definition of heritable trait (H) | ||||
HX | Unknown or insufficient evidence of a germline RB1 gene mutation | |||
H0 | Germline RB1 gene mutation has been excluded (ie, based on genetic testing with a high-sensitivity assay) | |||
H1 | Known or presumed germline RB1 gene mutation, based on any of the following:
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