Toxicity of the most used chemotherapeutics and their influence on the fetus^[1]

Drug	Fetal abnormalities	Comments
Cisplatin	Impaired development, hypoacousia, neutropenia, ventriculomegaly, hair loss	–
Carboplatin	None	–
Paclitaxel	Myelosuppression, pyloric stenosis	Single case reports
Etoposide	Pancytopenia, hypoacousia, secondary leukemias	Case reports for BEP
Bleomycin	Syndactyly	–
Vinblastine	Syndactyly, plagiocephaly	Safer than etoposide

BEP: bleomycin, etoposide, and cisplatin.

Reference:

Amant F, Berveiller P, Boere IA, et al. Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting. Ann Oncol 2019; 30:1601.

Graphic 131168 Version 1.0

Toxicity of the most used chemotherapeutics and their influence on the fetus[1]