Exam | Periodicity | Age to start | Age to end | Select clinical indications |
Clinical examination with, in children, specific attention to signs of virilization or early puberty and measurement of blood pressure and, in patients who received radiotherapy, to occurrence of basal cell carcinomas within the radiotherapy field | Every 6 months | Birth | 17 years | |
Annual | 18 years | Indefinite | ||
Whole-body MRI without gadolinium enhancement | Annual | Birth | Indefinite | High cancer risk TP53 variant* or patient previously treated by chemotherapy or radiotherapy |
18 years | Indefinite | |||
Breast MRI | Annual | 20 years | 65 years | |
Brain MRI¶ | Annual | Birth | 18 years | High cancer risk TP53 variant |
18 years | 50 years | |||
Abdominal ultrasound | Every 6 months | Birth | 18 years | |
Urine steroids | Every 6 months | Birth | 18 years | When abdominal ultrasound does not allow a proper imaging of the adrenal glands |
Colonoscopy¶ | Every 5 years | 18 years | Indefinite | Only if the carrier received abdominal radiotherapy for the treatment of a previous cancer or if there is a familial history of colorectal tumors suggestive of an increased genetic risk |
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