IVIG: intravenous immune globulin; NSAID: nonsteroidal antiinflammatory drug; SCIG: subcutaneous immune globulin; IgA: immunoglobulin A.
* We generally avoid premedication in individuals who have not previously received IVIG or those who have not had an allergic or other mild reaction, as many individuals will tolerate IVIG without premedications, and this practice avoids unnecessary medications in many cases. An alternative approach, also reasonable, is to give premedications with the first dose, and, if no reaction occurs, omit them with subsequent doses. Patient values and preferences should be assessed.
¶ When premedications are used, we generally start with an NSAID, acetaminophen, and/or an antihistamine. Migraine prophylaxis may be reasonable for certain individuals. Glucocorticoids may also be reasonable; however, we generally avoid glucocorticoids, especially in individuals with immunodeficiency, reserving them for individuals for whom other approaches are ineffective. For individuals receiving regular IVIG infusions with premedications, it may be reasonable to reevaluate the need for premedications periodically.
Δ Other approaches besides premedication include:Do you want to add Medilib to your home screen?