Clinical features | Suggested parenteral antibiotic(s) |
Uncomplicated fever episode | One of the following:
|
Signs of sepsis | Consultation with an expert in pediatric critical care and infectious diseases is suggested |
Abdominal pain, rectal pain, perineal inflammation, or blood per rectum | One of the following:
|
Suspected Clostridioides difficile | Refer to UpToDate content on treatment of C. difficile in children |
Radiographically documented pneumonia | Combination therapy with:
|
Evidence of meningitis or new-onset neurologic signs | Combination therapy with:
|
Clinically suspected CVC infection | Combination therapy with:
|
Skin or soft tissue infection |
|
Known colonization with MRSA or penicillin- and cephalosporin-resistant Streptococcus pneumoniae | |
High prevalence of MRSA infections in the community |
MRSA: methicillin-resistant S. aureus; CVC: central venous catheter.
* The combination of vancomycin and piperacillin-tazobactam is associated with increased risk of acute kidney injury and should be avoided.
¶ Ceftaroline and daptomycin are alternatives but are not used routinely.
Δ Linezolid is an alternative for children known to be colonized with, or previously infected with, vancomycin-resistant gram-positive organisms but should be used with caution because it has been associated with neutropenia.Do you want to add Medilib to your home screen?