Canonical and noncanonical NF-kB pathways

NFkB: nuclear factor kappa-light-chain-enhancer of activated B cells; LPS: lipopolysaccharide; TNF: tumor necrosis factor; IkB: inhibitor of NFkB; NEMO: NFkB essential modulator; IKK: IkB kinase.

Modified from: Sun SC. The non-canonical NF-kB pathway in immunity and inflammation. Nat Rev Immunol 2017; 17:545.

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