Electron micrograph showing lamellar inclusions in distal tubular cells

Electron microscopy photomicrograph of distal tubules in a male patient with "classic" Fabry disease. The varied burden of globotriaosylceramide (Gb3) inclusions in distal tubular cells is illustrated by the relatively high level of inclusions in most cells (arrows) versus the relative paucity of inclusions in some cells (arrowhead).