Strategy | Initial dose and interval | Subsequent dose and interval adjustments |
Traditional approach for children >1 month and adolescents | Typically 15 mg/kg per dose IV every 6 to 8 hours[1]:
| Either:
|
AUC-guided approachΔ[2] | Generally requires consultation with a clinical pharmacist | Based on AUC-guided serum concentration monitoring (generally requires consultation with a clinical pharmacist) |
AUC: area under the curve; IV: intravenous; MRSA: methicillin-resistant Staphylococcus aureus.
* Serious infections may include, but are not limited to, infective endocarditis, pneumonia requiring hospitalization, osteomyelitis, central nervous system infection, and infection causing critical illness.
¶ The value of trough-monitoring before achieving steady state (usually on day 2 to 3 of treatment) is uncertain.
Δ Some experts suggest this approach for serious* MRSA infections in children of all ages.Do you want to add Medilib to your home screen?