Gas pain/gastrointestinal discomfort: Neonate (including newborn): Oral: Oral drops/solution (20 mg/0.3 mL): 0.3 mL 4 times daily as needed after meals and at bedtime; do not exceed 12 doses/24 hours; maximum daily dose: 240 mg/24 hours
Note: Refer to product specific labeling for approved pediatric ages.
Gas pain/gastrointestinal discomfort:
Infants and Children <2 years weighing <10.9 kg: Oral: 20 mg 4 times daily as needed after meals and at bedtime. Maximum daily dose: 240 mg/24 hours
Children <2 years weighing ≥10.9 kg and Children ≥2 to <12 years: Oral: 40 mg 4 times daily as needed after meals and at bedtime. Maximum daily dose: 480 mg/24 hours
Children ≥12 years and Adolescents: 40 to 125 mg 4 times daily as needed after meals and at bedtime; with some formulations, may administer a single 250 mg dose if needed; maximum daily dose: 500 mg/24 hours
There are no dosage adjustments provided in manufacturer's labeling; dosage adjustment unlikely due to the drug not being systemically absorbed.
There are no dosage adjustments provided in manufacturer's labeling; dosage adjustment unlikely due to the drug not being systemically absorbed.
(For additional information see "Simethicone: Drug information")
Gas retention: Oral: Usual dose: 40 to 125 mg 4 times daily as needed after meals and at bedtime; may administer single doses of up to 160 to 500 mg after meals or at bedtime, not to exceed a maximum daily dose of 500 mg/day
The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason A. Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.
Altered kidney function: No dosage adjustment necessary for any degree of kidney impairment (no systemic absorption) (Ref).
Hemodialysis, intermittent (thrice weekly): No dosage adjustment necessary (no systemic absorption) (Ref).
Peritoneal dialysis: No dosage adjustment necessary (no systemic absorption) (Ref).
CRRT: No dosage adjustment necessary (no systemic absorption) (Ref).
PIRRT (eg, sustained, low-efficiency diafiltration): No dosage adjustment necessary (no systemic absorption) (Ref).
There is no dosage adjustment provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to the drug not being systemically absorbed.
No data reported
Dosage form specific issues:
• Benzyl alcohol and derivatives: Some dosage forms may contain sodium benzoate/benzoic acid; benzoic acid (benzoate) is a metabolite of benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol derivative with caution in neonates. See manufacturer’s labeling.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule, Oral:
FT Gas Relief Extra Strength: 125 mg [contains fd&c blue #1 (brilliant blue), fd&c red #40 (allura red ac dye), quinoline yellow (d&c yellow #10)]
FT Gas Relief Ultra Strength: 180 mg [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow)]
Gas Relief Extra Strength: 125 mg [contains fd&c blue #1 (brilliant blue), fd&c red #40 (allura red ac dye), quinoline yellow (d&c yellow #10)]
Gas Relief Ultra Strength: 180 mg [DSC] [contains fd&c yellow #6 (sunset yellow)]
Gas-X Extra Strength: 125 mg [contains fd&c blue #1 (brilliant blue), fd&c red #40 (allura red ac dye), quinoline yellow (d&c yellow #10)]
Gas-X Ultra Strength: 180 mg [contains fd&c yellow #6 (sunset yellow)]
Phazyme: 180 mg [DSC]
Phazyme Maximum Strength: 250 mg [contains fd&c blue #1 (brilliant blue)]
Phazyme Ultra Strength: 180 mg [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow)]
Phazyme Ultra Strength: 180 mg [contains fd&c yellow #6 (sunset yellow)]
Simethicone Ultra Strength: 180 mg [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow)]
Generic: 125 mg, 180 mg
Liquid, Oral:
Gas-X Infant Drops: 20 mg/0.3 mL (30 mL) [alcohol free, no artificial color(s), no artificial flavor(s), saccharin free; contains polyethylene glycol (macrogol), sodium benzoate]
Strip, Oral:
Gas-X Childrens: 40 mg (16 ea) [contains alcohol, usp, fd&c red #40 (allura red ac dye); sweet cinnamon flavor]
Gas-X Extra Strength: 62.5 mg (18 ea) [contains alcohol, usp, fd&c red #40 (allura red ac dye)]
Suspension, Oral:
FT Gas Relief Infants: 20 mg/0.3 mL (30 mL) [alcohol free, saccharin free; contains benzoic acid]
Gas Relief: 20 mg/0.3 mL (30 mL [DSC]) [dye free; contains sodium benzoate; fruit flavor]
Gas Relief Infants: 20 mg/0.3 mL (30 mL) [dye free; contains sodium benzoate]
Infants Gas Relief: 20 mg/0.3 mL (30 mL [DSC]) [contains sodium benzoate]
Infants Gas Relief: 20 mg/0.3 mL (30 mL) [dye free; contains sodium benzoate]
Mylicon Infants Gas Relief: 20 mg/0.3 mL (15 mL) [contains d&c red #22 (eosine), sodium benzoate]
Mylicon Infants Gas Relief: 20 mg/0.3 mL (30 mL) [alcohol free, dye free, gluten free, saccharin free; contains sodium benzoate]
Simethicone Drops Infants: 20 mg/0.3 mL (30 mL) [dye free, no artificial color(s), no artificial flavor(s), saccharin free; contains sodium benzoate]
Teeny Tummy Gas Relief Drops: 20 mg/0.3 mL (30 mL) [alcohol free, gluten free, no artificial color(s), no artificial flavor(s), paraben free; contains sodium benzoate]
Generic: 40 mg/0.6 mL (30 mL)
Tablet Chewable, Oral:
FT Gas Relief: 80 mg [contains corn starch]
FT Gas Relief Extra Strength: 125 mg
Gas Relief: 80 mg [peppermint flavor]
Gas Relief: 80 mg [contains corn starch]
Gas Relief: 80 mg [DSC] [lactose free]
Gas Relief Extra Strength: 125 mg
Gas Relief Extra Strength: 125 mg [DSC] [contains fd&c red #40(allura red ac)aluminum lake]
Gas Relief Extra Strength: 125 mg [lactose free; contains quinoline (d&c yellow #10) aluminum lake]
Gas-X: 80 mg [DSC]
Gas-X Extra Strength: 125 mg [DSC]
Gas-X Extra Strength: 125 mg [contains quinoline (d&c yellow #10) aluminum lake; peppermint creme flavor]
Gas-X Extra Strength: 125 mg [contains soy protein]
Gas-X Extra Strength: 125 mg [contains soy protein; cherry cream flavor]
Heartland Gas Relief: 80 mg [contains corn starch]
Mi-Acid Gas Relief: 80 mg [DSC] [peppermint flavor]
Phazyme: 125 mg [cool mint flavor]
Phazyme: 125 mg [DSC] [contains aspartame]
Generic: 80 mg, 125 mg
May be product dependent
Capsules (Gas-X Extra Strength Oral)
125 mg (per each): $0.20
Capsules (Gas-X Ultra Strength Oral)
180 mg (per each): $0.31
Capsules (Phazyme Maximum Strength Oral)
250 mg (per each): $0.43
Capsules (Phazyme Ultra Strength Oral)
180 mg (per each): $0.24
Capsules (Simethicone Oral)
125 mg (per each): $0.15
180 mg (per each): $0.17
Chewable (Gas-X Extra Strength Oral)
125 mg (per each): $0.25
Chewable (Phazyme Oral)
125 mg (per each): $0.19
Chewable (Simethicone Oral)
80 mg (per each): $0.02 - $0.24
125 mg (per each): $0.06
Liquid (Gas-X Infant Drops Oral)
20 mg/0.3 mL (per mL): $0.28
Strip (Gas-X Childrens Oral)
40 mg (per each): $0.34
Strip (Gas-X Extra Strength Oral)
62.5 mg (per each): $0.24
Suspension (Mylicon Infants Gas Relief Oral)
20 mg/0.3 mL (per mL): $0.35
Suspension (Simethicone Oral)
40 mg/0.6 mL (per mL): $0.24
Tablets (Bicarsim Oral)
80 mg (per each): $0.33
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Oral:
Chewable tablet: Chew thoroughly and swallow.
Suspension (drops): Shake well before using. Fill enclosed dropper to recommended dosage level and dispense slowly in mouth towards inner cheek. May mix with 30 mL water, infant formula, or other liquids.
Strips: Allow to dissolve on tongue.
Oral: Chewable tablet: Chew thoroughly and swallow
Oral suspension (drops): Shake well before using; may mix with 30 mL water or other liquids.
Oral strips: Allow to dissolve on tongue.
Store at 20°C to 25°C (68°F to 77°F). Protect from moisture. Avoid high humidity and excessive heat.
Oral suspension: Do not freeze.
Relief of pressure, bloating, fullness, and discomfort of gastrointestinal gas (FDA approved in all ages); Note: OTC: Approved ages and uses for generic products may vary; consult labeling for specific information.
Simethicone may be confused with cimetidine
Mylanta may be confused with Mynatal
Mylicon may be confused with Modicon, Myleran
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program
There are no known significant interactions.
Avoid carbonated beverages and gas-forming foods.
Simethicone is physiologically inert and not absorbed systemically following oral administration (Danhof 1974).
Decreases the surface tension of gas bubbles thereby disperses and prevents gas pockets in the GI system
Absorption: Not systemically absorbed (Danhof 1974; Hagemann 1998).
Excretion: Feces.
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