G6PD: glucose-6-phosphate dehydrogenase; CBC: complete blood count.
* Normal ranges for G6PD activity may vary depending on the assay method; the normal reference range provided by the testing laboratory should be used.
¶ Hemolysis can falsely lower the G6PD activity in a biochemical test. If G6PD activity is decreased during hemolysis, the diagnosis is confirmed.
Δ Refer to UpToDate for a detailed list.
◊ For individuals with episodic hemolysis, monitor CBC and reticulocyte count during acute infections or hospitalization; those with chronic hemolysis may require more frequent monitoring according to an individualized schedule. If the activity is not decreased (normal or borderline) in the midst of a hemolytic episode, it should be repeated.
§ In a child, may present as neonatal jaundice.
¥ A female with skewed X-inactivation may have negative (or borderline) results from a biochemical assay. It may be reasonable to test first-degree relatives.Do you want to add Medilib to your home screen?