Drug | Dose | Comments |
Acetaminophen | Doses should be reduced for patients with hepatic or significant renal dysfunction. | |
Oral |
| Usual dosing interval for pain management is every 6 hours. |
Intravenous |
| Usual dosing interval for pain management is every 6 hours. |
Rectal |
| Rate of absorption and bioavailability of rectal administration are highly variable; safety of multiple rectal doses following a loading dose is unknown. |
Ibuprofen | ||
Oral |
| |
Intravenous |
| Not FDA approved for children <3 months of age. FDA approved for children 3 to 6 months of age as a single, one time only dose for acute pain or fever. |
Ketorolac | ||
6 months to 2 years of age |
| |
2 to 16 years of age |
| Some clinicians recommend a maximum of 12 doses. |
>16 years of age and >50 kg |
| Some clinicians recommend a maximum of 12 doses. For children in this age <50 kg, some sources recommend a maximum of 15 mg/dose and a maximum daily dose of 60 mg/day. |
IV: intravenous; FDA: Food and Drug Administration.
* Hepatoxicity has occurred at manufacturer recommended maximum doses. Many experts recommend maximum doses of 3000 to 3250 mg/day, lower doses in patients with liver or kidney dysfunction. These maximum doses apply to short-term (eg, 3 to 5 days) administration.Do you want to add Medilib to your home screen?