Effect of addition of remifentanil to probability of response to noxious stimulus, at different concentrations of propofol (A) and sevoflurane (B).
From: Kuizenga MH, Colin PJ, Reyntjens KM, et al. Population Pharmacodynamics of Propofol and Sevoflurane in Healthy Volunteers Using a Clinical Score and the Patient State Index: A Crossover Study. Anesthesiology 2019; 131:1223. DOI:
10.1097/ALN.0000000000002966. Copyright © 2019 the American Society of Anesthesiologists. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.