Genotype | Risk for iron overload and its complications* | Testing/interventions |
C282Y/C282Y -or- C282Y/H63D |
|
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C282Y/wildtype -or- H63D/wildtype-or- H63D/H63D |
|
|
Negative for C282Y and H63DΔ |
|
|
HFE: hereditary hemochromatosis gene; HH: hereditary hemochromatosis; CLIA: Clinical Laboratory Improvement Amendments.
* Complications of iron overload may include:¶ Conditions other than HFE-associated HH that can cause or exacerbate iron overload include:
Δ Refer to UpToDate for caveats regarding genetic test results, including the need to confirm testing in a CLIA-certified laboratory, and settings in which more extensive genetic testing may be indicated.
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