Infectious agent | Antibiotic regimen¶ | Dosing |
Staphylococci, methicillin susceptible | One of the following: | |
| 300 to 450 mg twice daily | |
| 500 to 750 mg once daily | |
| 500 to 750 mg twice daily | |
| 500 mg three times daily | |
| 300 to 450 mg three times daily | |
Staphylococci, methicillin resistant | One of the following: | |
| 300 to 450 mg twice daily | |
| 500 to 750 mg once daily | |
| 500 to 750 mg twice daily | |
| 500 mg three times daily | |
| 300 to 450 mg three times daily | |
| 600 mg twice daily | |
Gram-negative organisms | One of the following: | |
| 500 to 750 mg twice daily | |
| 500 to 750 mg once daily | |
| 1 double-strength tablet twice daily | |
Penicillin-sensitive streptococci | One of the following: | |
| 750 to 1000 mg three times daily | |
| 300 to 450 mg three times daily |
* Following at least two weeks of parenteral therapy, completion of treatment with oral therapy may be reasonable in some circumstances; refer to UpToDate for further discussion.
¶ The choice of antibiotic regimen should be based on susceptibility, as well as patient drug allergies, intolerances, and potential drug-drug interactions or contraindications to a specific agent.
Δ Rifampin should not be used alone; it must be combined with a second agent to reduce the likelihood of selection for drug resistance.
◊ Fusidic acid is not available in the United States. Fusidic acid should not be used alone; it must be combined with a second agent to reduce the likelihood of selection for drug resistance. When rifampicin is combined with fusidic acid, fusidic acid levels may be reduced.[1]
§ Ciprofloxacin and levofloxacin have activity against Pseudomonas aeruginosa. For P. aeruginosa the higher dose range of fluoroquinolone should be used; ciprofloxacin 750 mg every 12 hours or levofloxacin 750 mg once daily.Data from:
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