Technique | Cytogenetic analysis | FISH analysis | Microarray analysis | Next-generation sequencing |
Resolution | 5 Mb | 100 to 300 kb | Variable to few kb | Single nucleotide |
Lower limit of detection | 5% | ~1 to 5% | 15 to 20% | 2 to 20% |
Detects copy-neutral LOH | No | No | Yes | Maybe |
Cell division required | Yes | No | No | No |
Detects balanced translocations/inversions | Yes | Yes | No | Yes/No |
Detects unbalanced aberrations, eg, deletions, unbalanced translocations | Yes | Yes | Yes | Yes/No |
Detects multiple clones | Yes | Yes/No | No | Yes/No |
Screen for novel lesions | Yes | No | Yes | Yes |
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