Bolus: 80 units/kg (using total body weight) Maximum = 10,000 units | ||
Initial infusion rate: 18 units/kg/hr (using total body weight) Maximum = 2000 units/hour | ||
If using anti-factor Xa activity* (IU/mL) | Response | If using aPTT* (seconds)¶ |
0.00 to 0.09 |
| <40 |
0.10 to 0.19 |
| 40 to 49 |
0.20 to 0.29 |
| 50 to 69 |
0.30 to 0.7 |
| 70 to 110¶ |
0.71 to 0.79 |
| 111 to 120 |
0.80 to 0.89 |
| 121 to 130 |
0.90 to 0.99 |
| 131 to 140 |
1.00 to 1.09 |
| 141 to 150 |
≥1.10 |
| >150 |
aPTT: activated partial thromboplastin time; VTE: venous thromboembolism; IU: international units.
* Only one measurement (the anti-factor Xa activity level or the aPTT) should be used; they are rarely concordant. If aPTT is used to adjust heparin, check with your laboratory to determine the aPTT values (in seconds) that would correspond to the anti-factor Xa values in this table.
¶ The therapeutic ranges for the aPTT (corresponding to an anti-factor Xa activity of 0.3 to 0.7 IU/mL) are dependent on local reagents and instrumentation and must be established by each individual institution.Do you want to add Medilib to your home screen?