Legend: | |||||||
Italics | Not available in the US | ||||||
Estimated rate of cross-reactivity between two intersecting cephalosporins is <2% | |||||||
Parenteral forms of cephalosporins available in the US | |||||||
Identical drugs that intersect on the X and Y axes | |||||||
X | Drugs that have identical or very similar R1 side groups (higher risk of cross-reactivity) | ||||||
* | Drugs that have less similar side chain groups, but cross reactivity is assumed to be possible | ||||||
4th generation cephalosporins | 5th generation cephalosporins | Monobactam | |||||
Cefepime | Cefpirome | Ceftaroline fosamil | Ceftolozane | Cefiderocol | Aztreonam | ||
1st | Cefadroxiloral | ||||||
Cefatrizine | |||||||
Cephalexinoral | |||||||
Cefazolinpar | |||||||
Ceftezole | |||||||
Cephalothin | |||||||
Cephapirin | |||||||
2nd | Cefoxitinpar | ||||||
Cefuroximeoral, par | * | * | * | ||||
Cefotetanpar | |||||||
Cefproziloral | |||||||
Cefaclororal | |||||||
Cefonicid | |||||||
Cefamandole | |||||||
3rd | Cefoperazone | ||||||
Ceftibutenoral | |||||||
Cefdiniroral | |||||||
Cefiximeoral | |||||||
Ceftriaxonepar | X | X | |||||
Cefditorenoral | X | X | |||||
Cefodizime | X | X | |||||
Cefotaximepar | X | X | |||||
Cefpodoximeoral | X | X | |||||
Ceftazidimepar | * | * | X | X | |||
4th | Cefepimepar | X | |||||
Cefpirome | X | ||||||
5th | Ceftaroline fosamilpar | ||||||
Ceftolozanepar | |||||||
Cefiderocol | X | ||||||
Monobactam | Aztreonampar | X |
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