Legend: | |||||||||||
Italics | Not available in the US | ||||||||||
Estimated rate of cross-reactivity between two intersecting cephalosporins is <2% | |||||||||||
Parenteral forms of cephalosporins available in the US | |||||||||||
Identical drugs that intersect on the X and Y axes | |||||||||||
X | Drugs that have identical or very similar R1 side groups (highest risk of cross-reactivity) | ||||||||||
R2 | Drugs that have identical or very similar R2 side groups (lower risk of cross-reactivity) | ||||||||||
* | Drugs that have less similar side chain groups, but cross reactivity is assumed to be possible | ||||||||||
3rd generation cephalosporins | |||||||||||
Cefoperazone | Ceftibuten | Cefdinir | Cefixime | Ceftriaxone | Cefditoren | Cefodizime | Cefotaxime | Cefpodoxime | Ceftazidime | ||
1st | Cefadroxiloral | ||||||||||
Cefatrizine | |||||||||||
Cephalexinoral | |||||||||||
Cefazolinpar | |||||||||||
Ceftezole | |||||||||||
Cephalothin | R2 | ||||||||||
Cephapirin | R2 | ||||||||||
2nd | Cefoxitinpar | ||||||||||
Cefuroximeoral, par | * | * | * | * | * | * | |||||
Cefotetanpar | X | ||||||||||
Cefproziloral | |||||||||||
Cefaclororal | |||||||||||
Cefonicid | |||||||||||
Cefamandole | X | ||||||||||
3rd | Cefoperazone | ||||||||||
Ceftibutenoral | |||||||||||
Cefdiniroral | X | ||||||||||
Cefiximeoral | X | ||||||||||
Ceftriaxonepar | X | X | X | X | * | ||||||
Cefditorenoral | X | X | X | X | * | ||||||
Cefodizime | X | X | X | X | * | ||||||
Cefotaximepar | X | X | X | X | * | ||||||
Cefpodoximeoral | X | X | X | X | * | ||||||
Ceftazidimepar | * | * | * | * | * | ||||||
4th | Cefepimepar | X | X | X | X | X | * | ||||
Cefpirome | X | X | X | X | X | * | |||||
5th | Ceftaroline fosamilpar | ||||||||||
Ceftolozanepar | |||||||||||
Cefiderocol | X | ||||||||||
Monobactam | Aztreonampar | X |
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