Legend: | ||||||||
Italics | Not available in the US | |||||||
Estimated rate of cross-reactivity between two intersecting cephalosporins is <2% | ||||||||
Parenteral forms of cephalosporins available in the US | ||||||||
Identical drugs that intersect on the X and Y axes | ||||||||
X | Drugs that have identical or very similar R1 side groups (highest risk of cross-reactivity) | |||||||
R2 | Drugs that have identical or very similar R2 side groups (lower risk of cross-reactivity) | |||||||
* | Drugs that have less similar side chain groups, but cross reactivity is assumed to be possible | |||||||
2nd generation cephalosporins | ||||||||
Cefoxitin | Cefuroxime | Cefotetan | Cefprozil | Cefaclor | Cefonicid | Cefamandole | ||
1st | Cefadroxiloral | X | X | |||||
Cefatrizine | X | X | ||||||
Cephalexinoral | X | X | ||||||
Cefazolinpar | ||||||||
Ceftezole | ||||||||
Cephalothin | X | |||||||
Cephapirin | ||||||||
2nd | Cefoxitinpar | R2 | ||||||
Cefuroximeoral, par | R2 | |||||||
Cefotetanpar | X | |||||||
Cefproziloral | X | |||||||
Cefaclororal | X | |||||||
Cefonicid | X | |||||||
Cefamandole | X | X | ||||||
3rd | Cefoperazone | X | X | |||||
Ceftibutenoral | ||||||||
Cefdiniroral | ||||||||
Cefiximeoral | ||||||||
Ceftriaxonepar | * | |||||||
Cefditorenoral | * | |||||||
Cefodizime | * | |||||||
Cefotaximepar | * | |||||||
Cefpodoximeoral | * | |||||||
Ceftazidimepar | * | |||||||
4th | Cefepimepar | * | ||||||
Cefpirome | * | |||||||
5th | Ceftaroline fosamilpar | * | ||||||
Ceftolozanepar | ||||||||
Cefiderocol | ||||||||
Monobactam | Aztreonampar |
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