Legend: | ||||||||
Italics | Not available in the US | |||||||
Estimated rate of cross-reactivity between two intersecting cephalosporins is <2% | ||||||||
Parenteral forms of cephalosporins available in the US | ||||||||
Identical drugs that intersect on the X and Y axes | ||||||||
X | Drugs that have identical or very similar R1 side groups (highest risk of cross-reactivity) | |||||||
R2 | Drugs that have identical or very similar R2 side groups (lower risk of cross-reactivity) | |||||||
1st generation cephalosporins | ||||||||
Cefadroxil | Cefatrizine | Cephalexin | Cefazolin | Ceftezole | Cephalothin | Cephapirin | ||
1st | Cefadroxiloral | X | X | |||||
Cefatrizine | X | X | ||||||
Cephalexinoral | X | X | ||||||
Cefazolinpar | X | |||||||
Ceftezole | X | |||||||
Cephalothin | R2 | |||||||
Cephapirin | R2 | |||||||
2nd | Cefoxitinpar | X | ||||||
Cefuroximeoral, par | ||||||||
Cefotetanpar | ||||||||
Cefproziloral | X | X | X | |||||
Cefaclororal | X | X | X | |||||
Cefonicid | ||||||||
Cefamandole | ||||||||
3rd | Cefoperazone | |||||||
Ceftibutenoral | ||||||||
Cefdiniroral | ||||||||
Cefiximeoral | ||||||||
Ceftriaxonepar | ||||||||
Cefditorenoral | ||||||||
Cefodizime | ||||||||
Cefotaximepar | R2 | R2 | ||||||
Cefpodoximeoral | ||||||||
Ceftazidimepar | ||||||||
4th | Cefepimepar | |||||||
Cefpirome | ||||||||
5th | Ceftaroline fosamilpar | |||||||
Ceftolozanepar | ||||||||
Cefiderocol | ||||||||
Monobactam | Aztreonampar |
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