VUS: variant of uncertain significance; rrBSO: risk-reducing bilateral salpingo-oophorectomy.
* Ensure that the genetic testing is performed properly, the patient identification is correct, and the interpretation of pathogenicity is accurate based on the most recent data analysis.
¶ Pathogenic and likely pathogenic variants are treated the same for purposes of surveillance and risk reduction interventions; these interventions are independent of family history.
Δ VUSs lack sufficient information from clinical and bench research to be classified as pathogenic or benign. Continue to seek updated interpretation of pathogenicity periodically (eg, annually).
◊ Lynch syndrome cancers include colorectal, endometrial, ovarian, urinary tract, gastric and small bowel, hepatobiliary and pancreatic, brain, and skin. Refer to UpToDate for the age at which interventions are initiated, the frequency at which they are performed (eg, delay of rrBSO until after childbearing), and the evidence to support these interventions.Do you want to add Medilib to your home screen?