Genotype | Clinical findings | Interventions |
Heterozygous sickle mutation (sickle cell trait) |
|
|
Homozygous sickle mutation or compound heterozygosity with another beta globin variant¶ (sickle cell disease) |
|
|
UTI: urinary tract infection; CKD: chronic kidney disease; VTE: venous thromboembolism; HbA1C: glycosylated hemoglobin; G-CSF: granulocyte colony-stimulating factor.
* Bleeding in the anterior chamber of the eye.
¶ Includes structural variants such as hemoglobin C and quantitative variants such as beta thalassemia. Disease severity depends on the nature of the other beta globin mutation as well as other mediators. As an example, sickle-beta0-thalassemia is generally more severe than sickle-beta+-thalassemia or hemoglobin sickle cell disease. However, all individuals with sickle cell disease require comprehensive care by a multidisciplinary team. Refer to UpToDate for more information.Do you want to add Medilib to your home screen?