Volume of distribution |
Increased fat mass |
Increased lean body mass |
Increased total body water |
Increased blood volume |
Increased cardiac output |
Organomegaly |
Protein binding* |
Possible increased lipoproteins (eg, cholesterol or triglycerides) |
Altered alpha1-acid glycoprotein |
Drug metabolism |
Increased activity of some CYP P450 enzymes¶ |
Increased phase II drug metabolism via glucuronidation and sulfation |
Excretion |
Increased renal blood flow |
Increased GFR |
Increased renal tubular secretion and reabsorption |
Individual organ system comorbid conditions |
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