Grade | Mandard | AJCC 2010 | Rödel | MSKCC |
TRG 0 | – | No residual tumor cells | No regression | – |
TRG 1 | Absence of residual cancer, with fibrosis extending through the various layers of the oesophageal wall (complete regression) | Single cells or small groups | Fibrosis <25% of tumor mass | 100% response |
TRG 2 | Rare residual cancer cells scattered through the fibrosis | Residual cancer with desmoplastic response | Fibrosis 25 to 50% of tumor mass | 86 to 99% response |
TRG 3 | An increase in the number of residual cancer cells, but fibrosis still predominates | Minimal evidence of tumor response | Fibrosis >50% of tumor mass | <86% response |
TRG 4 | Residual cancer outgrowing fibrosis | – | Complete regression | – |
TRG 5 | Absence of regressive changes | – | – | – |
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