Antibiotic agent | Antibiotic concentration | Heparin concentration | Maximum dwell time (duration of stability)* | References | |
Antibiotic agents with activity against gram-positive organisms | Vancomycin | 2.5 mg/mL¶ | 2500 units/mL | 72 hours | Krishnasami[1] |
5 mg/mLΔ | 5000 units/mL | 72 hours | Luther[2] | ||
5 mg/mL | none | 72 hours | Luther[2] | ||
Cefazolin | 5 mg/mL◊ | 2500 units/mL | 72 hours | Krishnasami[1] | |
5 mg/mL§ | none | 48 hours | Vercaigne[3] | ||
10 mg/mL | 5000 units/mL | 72 hours | Vercaigne[3] | ||
Daptomycin | 5 mg/mL¥ | 5000 units/mL | 72 hours | LaPlante[4] | |
5 mg/mL | none | 72 hours | LaPlante[4] | ||
Nafcillin | 100 mg/mL | none | 12 hours | Nafcillin[5] | |
Ampicillin | 10 mg/mL‡ | none | 8 hours | Ampicillin[6] | |
Antibiotic agents with activity against gram-negative organisms | Gentamicin | 1 mg/mL† | 2500 units/mL | 72 hours | Krishnasami[1] |
5 mg/mL** | 5000 units/mL | 72 hours | Vercaigne[3] | ||
5 mg/mL | none | 72 hours | Vercaigne[3] | ||
Ceftazidime | 10 mg/mL¶¶ | 5000 units/mL | 48 hours | Vercaigne[3] | |
1 to 10 mg/mL | none | 48 hours | Lee[7] | ||
Cefepime | 1 to 10 mg/mL | none | 48 hours | Lee[7] | |
Ciprofloxacin | 1 to 5 mg/mL | none | 48 hours | Lee[7], Lee[8] | |
Ceftriaxone | 100 mg/mL | none | 48 hours | Ceftriaxone[9] |
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