IgG4-RD | Sjögren's disease | |
Gender distribution | 2.5:1 male:female ratio | 9:1 female:male ratio |
Clinical presentation | Mild or no salivary gland dysfunction | Significant salivary gland dysfunction (xerostomia) |
Persistent salivary gland swelling | Intermittent salivary gland swelling | |
Circulating antibodies | Serum IgG4 and IgE levels typically elevated | Serum IgG4 and IgE levels usually normal |
Anti-Ro/SSA and anti-LA/SSB rarely present | Anti-Ro/SSA (with or without anti-LA/SSB) commonly present | |
ANA detectable in 25% of patients | ANA detectable in 90% of patients | |
Rheumatoid factor detected in 25% of patients | Rheumatoid factor detected in 60% of patients | |
Imaging | No abnormality of salivary glands seen on sialography | Punctate and globular sialectasis seen on sialography |
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