Starting dose (oral or intravenous*) | Maximum effective dose¶ (higher individual doses or more frequent dosing intervals are unlikely to produce substantial additional diuresis)Δ | Maximal recommended daily dose¶ (greater daily total doses are associated with a risk for toxicity) | |||||||
Furosemide | Bumetanide | Torsemide | Furosemide | Bumetanide | Torsemide | Furosemide | Bumetanide | Torsemide | |
Heart failure◊ | 20 mg once or twice daily | 0.5 mg once or twice daily | 5 mg once daily | 80 mg 3 times daily | 3 mg 3 times daily | 50 mg twice daily | 600 mg | 10 mg | 200 mg |
Cirrhotic ascites§ | 40 mg once or twice daily | 1 mg once or twice daily | 10 mg once daily | 40 mg 3 times daily | 1 mg 3 times daily | 20 mg twice daily | 160 mg | 4 mg | 40 mg |
Nephrotic syndrome | 40 mg once or twice daily | 1 mg once or twice daily | 10 mg once daily | 120 mg 3 times daily | 3 mg 3 times daily | 50 mg twice daily | 600 mg | 10 mg | 200 mg |
Chronic kidney disease¥ | ‡ | ‡ | ‡ | 200 mg 3 times daily | 10 mg 3 times daily | 100 mg twice daily | 600 mg | 10 mg | 200 mg |
Acute kidney injury | 80 mg once or twice daily | 2 mg once or twice daily | 20 mg once daily | 500† mg once | Not reported | Not reported | 600 mg | Not reported | Not reported |
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