Introduction — This topic includes links to society and government-sponsored guidelines from selected countries and regions around the world. We will update these links periodically; newer versions of some guidelines may be available on each society's website. Some societies may require users to log in to access their guidelines.
The recommendations in the following guidelines may vary from those that appear in UpToDate topic reviews. Readers who are looking for UpToDate topic reviews should use the UpToDate search box to find the relevant content.
Links to related guidelines are provided separately. (See "Society guideline links: Liver resection and ablation" and "Society guideline links: Alcohol-associated liver disease" and "Society guideline links: Hepatitis C virus infection".)
International
●Society for Immunotherapy of Cancer (SITC): Clinical practice guideline on immunotherapy for the treatment of gastrointestinal cancer (2023)
●SITC: Clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma (2021)
●International Liver Cancer Association (ILCA): White paper on biomarker development for hepatocellular carcinoma (2021)
●ILCA: Systemic therapy guidance for hepatocellular carcinoma (2020)
●International Liver Transplantation Society (ILTS): Working group report from the ILTS Transplant Oncology Consensus Conference on liver transplantation for hepatocellular carcinoma (2020)
●World Gastroenterology Organisation (WGO): Global guideline on hepatocellular carcinoma − A global perspective (2009)
Canada
●Cancer Care Ontario (CCO): Non-surgical management of advanced hepatocellular carcinoma (2019)
●CCO: Focal tumour ablation − Transarterial chemoembolization for hepatocellular carcinoma (2015)
●CCO: Focal tumor ablation − Thermal ablation of hepatocellular carcinoma and metastases from colorectal carcinoma (2014)
United States
●American College of Radiology (ACR): Liver Reporting and Data System (LI-RADS) for hepatocellular carcinoma (HCC)
●National Cancer Institute (NCI): Liver (hepatocellular) cancer screening – Health professional version
●American Society of Clinical Oncology (ASCO): Guideline on systemic therapy for advanced hepatocellular carcinoma, update (2024)
●American Association for the Study of Liver Diseases (AASLD): Practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma (2023)
●AASLD: Practice guidance on palliative care and symptom-based management in decompensated cirrhosis (2022)
●ACR: ACR Appropriateness Criteria for management of liver cancer (2022)
●American Gastroenterological Association (AGA): Clinical practice guideline on systemic therapy for hepatocellular carcinoma (2022)
●AGA: Clinical practice update on palliative care management in cirrhosis – Expert review (2021)
Europe
●European Association for the Study of the Liver (EASL): Position paper for systemic treatment of hepatocellular carcinoma (2021)
●European Society for Medical Oncology (ESMO): Updated treatment recommendations for hepatocellular carcinoma (HCC) (2021)
•ESMO: Clinical practice guidelines for diagnosis, treatment, and follow-up of hepatocellular carcinoma (2018)
●EASL: Clinical practice guidelines − Management of hepatocellular carcinoma (2018)
United Kingdom
●National Institute for Health and Care Excellence (NICE): Interventional procedures guidance on image-guided percutaneous laser ablation for primary and secondary liver tumours (2024)
●NICE: Interventional procedures guidance on selective internal radiation therapy for primary hepatocellular carcinoma (2013)
●NICE: Interventional procedures guidance on microwave ablation of hepatocellular carcinoma (2007)
India
●Indian Council of Medical Research (ICMR): Consensus document for management of hepatocellular carcinoma (2019)
●Indian National Association for Study of the Liver (INASL): Consensus on prevention, diagnosis, and management of hepatocellular carcinoma in India – The Puri II recommendations, update (2019)
●Asian Pacific Association for the Study of the Liver (APASL): Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma, update (2017)
Australia–New Zealand
●Gastroenterological Society of Australia (GESA): Australian recommendations for the management of hepatocellular carcinoma – A consensus statement (2020)
●Asian Pacific Association for the Study of the Liver (APASL): Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma, update (2017)
Japan
●Pan-Asian adapted European Society for Medical Oncology (ESMO) clinical practice guidelines for the management of patients with intermediate and advanced/relapsed hepatocellular carcinoma (2020)
●Japan Society of Hepatology (JSH): Clinical practice guidelines for hepatocellular carcinoma (4th JSH HCC guidelines), update (2019)
●Asian Pacific Association for the Study of the Liver (APASL): Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma, update (2017)