Drug | Initial dose | Route | Frequency | Titration | Max dose | Cost* | Special considerations |
Loperamide | 4 mg | PO | Three times daily with meals or every 6 hours with enteral nutrition | By 2 mg | 16 mg/day | $ | Avoid liquid due to propylene glycol content |
Diphenoxylate/atropine | 2.5 mg/0.025 mg (1 tablet) | PO | Three times daily with meals or every 6 hours with enteral nutrition | By 1 tablet | 2 tablets four times daily (20 mg diphenoxylate) | $$ | Avoid liquid formulation due to sorbitol content |
Pantoprazole | 40 mg | IV | Twice daily | None | 40 mg twice daily | $$$ | Discontinue as soon as feasible |
Codeine | 15 mg | PO | Three times daily with meals, up to four times daily | By 15 mg | 45 mg four times daily | $$ | Monitor for CNS effects |
Octreotide | 100 mcg | SC | Three times daily | None | None | $$$ | Discontinue if output not decreased after 3 to 5 days |
Clonidine | 0.3 mg | Transdermal | Every 7 days | None | 0.3 mg every 7 days | $$$$ | Monitor HR and BP |
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