Risk group | Clinical/pathologic features |
Very low | - T1c AND
- Grade group 1 AND
- PSA <10 ng/mL AND
- Fewer than 3 prostate biopsy fragments/cores positive, ≤50% cancer in each fragment/core AND
- PSA density <0.15 ng/mL/g
|
Low | - T1 to T2a AND
- Grade group 1 AND
- PSA <10 ng/mL AND
- Does not qualify for very low risk
|
Favorable intermediate | - No high or very high risk features
- No more than one intermediate risk factor:
- T2b to T2c OR
- Grade group 2 or 3
- PSA 10 to 20 ng/mL
AND AND - Percentage of positive biopsy cores <50%
|
Unfavorable intermediate | - No high or very high risk features
- Two or three of the intermediate risk factors:
- T2b to T2c
- Grade group 2 or 3
- PSA 10 to 20 ng/mL
AND/OR AND/OR - ≥50% of positive biopsy cores
|
High | - No very high risk features
AND - T3a OR
- Grade group 4 or 5 OR
- PSA >20 ng/mL
|
Very high | - T3b to T4 OR
- Primary Gleason pattern 5 OR
- Two or three high-risk features OR
- >4 cores with Grade group 4 or 5
|