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High PEEP titration

High PEEP titration
Higher PEEP/lower FiO2
Step: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
FiO2 0.3 0.4 0.4 0.4 0.4 0.4 0.4 0.5 0.5 0.5 0.6 0.7 0.8 0.8 0.9 1.0 1.0
PEEP 5 5 8 10 12 14 16 16 18 20 20 20 20 22 22 22 24
FiO2: fraction of inspired oxygen; PEEP: positive end-expiratory pressure.
Adapted from:
  1. Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. NEJM 2004; 351:327.
  2. Meade MO, Cook DJ, Guyatt GH. Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008; 299:637.
Graphic 118834 Version 2.0

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