Monoclonal immunoglobulin deposits | Main characteristics of monoclonal gammopathy | Main involved organ(s) | |
Immunoglobulin deposition in tissue* | |||
AL amyloidosis | Fibrillar |
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Type I cryoglobulinemia | Microtubular/crystalline |
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Immunotactoid glomerulopathy/GOMMID | Microtubular |
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Acquired Fanconi syndrome | Crystalline |
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Crystal storing histiocytosis | Crystalline |
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Crystalline keratopathy | Crystalline |
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Monoclonal immunoglobulin deposition disease (MIDD) | Non-organized |
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Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) | Non-organized |
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Macroglobulinosis | Non-organized |
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Autoantibody activity | |||
Type II mixed cryoglobulinemia¶ | Rheumatoid |
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C1 inhibitor deficiency | C1 inhibitor |
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Von Willebrand (vW) disease | vW factor |
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Bullous skin diseases | Dermo-epidermal junction (collagen VII) |
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Xanthomatosis | Various lipoproteins |
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Cold agglutinin disease | Red blood cell (Ii) |
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IgM associated peripheral neuropathy | Myelin associated glycoprotein (MAG) +++ Gangliosides |
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CAP¶ activation | |||
C3 glomerulonephritis | Mechanism to be determined Autoantibody activity against CAP regulator protein (factor H) in some cases |
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Atypical hemolytic-uremic syndrome (HUS) | Mechanism to be determined Autoantibody activity against CAP regulator protein (factor H) in some cases |
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Cytokine-mediated | |||
POEMS syndrome | Vascular endothelial growth factor |
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Unknown mechanism | |||
Systemic capillary leak syndrome |
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TEMPI syndrome |
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Neutrophilic dermatosisΔ |
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Acquired cutis laxa |
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Scleromyxedema |
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Scleredema |
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Schnitzler's syndrome | Acquired auto-inflammatory syndrome by IL-1 deregulation? |
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Sporadic late onset nemaline myopathy (SLONM) |
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