Commonly used perioperative drugs that may prolong the QT interval*[1-5]
Commonly used perioperative drugs that may prolong the QT interval*[1-5]
Drug class
Example
Antiarrhythmics
Amiodarone¶
Inhaled anesthetics
Sevoflurane
Desflurane
Isoflurane
Antiemetics
Ondansetron
Droperidol
Haloperidol
Opioids
Methadone
More detailed information is available in UpToDate topics on acquired long QT syndrome and in a separate table.
* An updated list of all QT prolonging medications is available at www.torsades.org. ¶ In contrast with other class III antiarrhythmic drugs, amiodarone is rarely associated with torsades de pointes (TdP); refer to accompanying text within UpToDate topic review of acquired long QT syndrome.
References:
O'Hare M, Maldonado Y, Munro MJ et al. Perioperative management of patients with congenital or acquired disorders of the QT interval. Br J Anesth 2018; 120:629.
Roden DM. Drug-Induced prolongation of the QT interval. N Engl J Med 2004; 350:1013. Kaye AD, Volpi-Abadie J, Bensler JM. QT interval abnormalities: risk factors and perioperative management in long QT syndromes and Torsades de Pointes. J Anesth 2013; 27:575.
Uvelin A, Pejaković J, Mijatović V. Acquired prolongation of QT interval as a risk factor for torsade de pointes ventricular tachycardia: a narrative review for the anesthesiologist and intensivist. J Anesth 2017; 31:413.
Fazio G, Vernuccio F, Grutta G, Re GL. Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management. World J Cardiol 2013; 26:87.
Fradley MG, Moslehi J. QT Prolongation and oncology drug development. Card Electrophysiol Clin 2015; 7:341.