Augmentation | End-of-dose rebound | Tolerance | Natural progression | Exacerbating factors* | |
Worse than before treatment | Yes | Yes, in early morning | No | Yes | Yes |
Earlier onset | Yes | Yes, in early morning | No | Yes | Yes |
Spread to arms | Yes | No | No | Yes | Yes |
Breakthrough at night | Yes | Yes, in early morning | Yes | Yes | Yes |
Worse with increased dose | Yes, but not immediately | No | No | No | No |
Improved with decreased dose | Yes, but not always¶ | No | No | No | No |
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