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Evaluation of persistent thrombocytosis

Evaluation of persistent thrombocytosis
Screening evaluation includes CBC/differential, blood smear, history and physical examination, and ferritin, as described in UpToDate content on evaluation of thrombocytosis. Clinical emergencies and complications (eg, thrombosis, bleeding) should be managed without delay by evaluation of thrombocytosis.

CBC: complete blood count; MPN: myeloproliferative neoplasm.

* Definitions:
  • Worrisome findings on smear: Leukemic blasts, leukoerythroblastosis
  • Persistent thrombocytosis: Platelets >450,000/microL confirmed on repeat CBC
  • Vasomotor symptoms: Erythromelalgia, flushing, pruritus
  • Constitutional symptoms: Fever, sweats, weight loss
  • Unusual thrombotic presentations (eg, unusual or multiple sites; <45 years old; unexplained, unprovoked, or recurrent thrombosis)

¶ Refer to UpToDate content on evaluation of thrombocytosis for details.

Δ Refer to UpToDate content on diagnostic testing for MPNs for details.
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