Type of reaction | Common features |
Non-allergic reaction | - Adverse effects (eg, diarrhea, vomiting, yeast vaginitis)
- Family history of penicillin allergy but no personal history
|
Mild non-IgE-mediated reaction | - Maculopapular rash (with or without itching)
- Medical record lists penicillin allergy but patient unaware of reaction
|
IgE-mediated reaction | - Anaphylaxis
- Angioedema
- Wheezing
- Laryngeal edema
- Hypotension
- Hives/urticaria
|
Serious delayed reactions | - Toxic epidermal necrolysis (TEN)
- Stevens-Johnson syndrome (SJS)
- Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DiHS)
- Other exfoliating dermatoses/erythroderma
- Serum sickness-like reactions
- Drug-induced cytopenias
- Drug-induced kidney, hepatic, or other specific organ damage
|