When TNM is... | And grade is... | And HER2 status is... | And ER status is... | And PR status is... | Then the pathological prognostic stage group is... |
Tis N0 M0 | Any | Any | Any | Any | 0 |
T1* N0 M0 T0 N1mi M0 T1* N1mi M0 | G1 | Positive | Positive | Positive | IA |
Negative | IA | ||||
Negative | Positive | IA | |||
Negative | IA | ||||
Negative | Positive | Positive | IA | ||
Negative | IA | ||||
Negative | Positive | IA | |||
Negative | IA | ||||
T1* N0 M0 T0 N1mi M0 T1* N1mi M0 | G2 | Positive | Positive | Positive | IA |
Negative | IA | ||||
Negative | Positive | IA | |||
Negative | IA | ||||
Negative | Positive | Positive | IA | ||
Negative | IA | ||||
Negative | Positive | IA | |||
Negative | IB | ||||
T1* N0 M0 T0 N1mi M0 T1* N1mi M0 | G3 | Positive | Positive | Positive | IA |
Negative | IA | ||||
Negative | Positive | IA | |||
Negative | IA | ||||
Negative | Positive | Positive | IA | ||
Negative | IA | ||||
Negative | Positive | IA | |||
Negative | IB | ||||
T0 N1¶ M0 T1* N1¶ M0 T2 N0 M0 | G1 | Positive | Positive | Positive | IA |
Negative | IB | ||||
Negative | Positive | IB | |||
Negative | IIA | ||||
Negative | Positive | Positive | IA | ||
Negative | IB | ||||
Negative | Positive | IB | |||
Negative | IIA | ||||
T0 N1¶ M0 T1* N1¶ M0 T2 N0 M0 | G2 | Positive | Positive | Positive | IA |
Negative | IB | ||||
Negative | Positive | IB | |||
Negative | IIA | ||||
Negative | Positive | Positive | IA | ||
Negative | IIA | ||||
Negative | Positive | IIA | |||
Negative | IIA | ||||
T0 N1¶ M0 T1* N1¶ M0 T2 N0 M0 | G3 | Positive | Positive | Positive | IA |
Negative | IIA | ||||
Negative | Positive | IIA | |||
Negative | IIA | ||||
Negative | Positive | Positive | IB | ||
Negative | IIA | ||||
Negative | Positive | IIA | |||
Negative | IIA | ||||
T2 N1Δ M0 T3 N0 M0 | G1 | Positive | Positive | Positive | IA |
Negative | IIB | ||||
Negative | Positive | IIB | |||
Negative | IIB | ||||
Negative | Positive | Positive | IA | ||
Negative | IIB | ||||
Negative | Positive | IIB | |||
Negative | IIB | ||||
T2 N1Δ M0 T3 N0 M0 | G2 | Positive | Positive | Positive | IB |
Negative | IIB | ||||
Negative | Positive | IIB | |||
Negative | IIB | ||||
Negative | Positive | Positive | IB | ||
Negative | IIB | ||||
Negative | Positive | IIB | |||
Negative | IIB | ||||
T2 N1Δ M0 T3 N0 M0 | G3 | Positive | Positive | Positive | IB |
Negative | IIB | ||||
Negative | Positive | IIB | |||
Negative | IIB | ||||
Negative | Positive | Positive | IIA | ||
Negative | IIB | ||||
Negative | Positive | IIB | |||
Negative | IIIA | ||||
T0 N2 M0 T1* N2 M0 T2 N2 M0 T3 N1Δ M0 T3 N2 M0 | G1 | Positive | Positive | Positive | IB |
Negative | IIIA | ||||
Negative | Positive | IIIA | |||
Negative | IIIA | ||||
Negative | Positive | Positive | IB | ||
Negative | IIIA | ||||
Negative | Positive | IIIA | |||
Negative | IIIA | ||||
T0 N2 M0 T1* N2 M0 T2 N2 M0 T3 N1Δ M0 T3 N2 M0 | G2 | Positive | Positive | Positive | IB |
Negative | IIIA | ||||
Negative | Positive | IIIA | |||
Negative | IIIA | ||||
Negative | Positive | Positive | IB | ||
Negative | IIIA | ||||
Negative | Positive | IIIA | |||
Negative | IIIB | ||||
T0 N2 M0 T1* N2 M0 T2 N2 M0 T3 N1Δ M0 T3 N2 M0 | G3 | Positive | Positive | Positive | IIA |
Negative | IIIA | ||||
Negative | Positive | IIIA | |||
Negative | IIIA | ||||
Negative | Positive | Positive | IIB | ||
Negative | IIIA | ||||
Negative | Positive | IIIA | |||
Negative | IIIC | ||||
T4 N0 M0 T4 N1Δ M0 T4 N2 M0 Any T N3 M0 | G1 | Positive | Positive | Positive | IIIA |
Negative | IIIB | ||||
Negative | Positive | IIIB | |||
Negative | IIIB | ||||
Negative | Positive | Positive | IIIA | ||
Negative | IIIB | ||||
Negative | Positive | IIIB | |||
Negative | IIIB | ||||
T4 N0 M0 T4 N1Δ M0 T4 N2 M0 Any T N3 M0 | G2 | Positive | Positive | Positive | IIIA |
Negative | IIIB | ||||
Negative | Positive | IIIB | |||
Negative | IIIB | ||||
Negative | Positive | Positive | IIIA | ||
Negative | IIIB | ||||
Negative | Positive | IIIB | |||
Negative | IIIC | ||||
T4 N0 M0 T4 N1Δ M0 T4 N2 M0 Any T N3 M0 | G3 | Positive | Positive | Positive | IIIB |
Negative | IIIB | ||||
Negative | Positive | IIIB | |||
Negative | IIIB | ||||
Negative | Positive | Positive | IIIB | ||
Negative | IIIC | ||||
Negative | Positive | IIIC | |||
Negative | IIIC | ||||
Any T Any N M1 | Any | Any | Any | Any | IV |
NOTES:
| |||||
Genomic profile for pathologic prognostic staging | |||||
When OncotypeDx score is less than 11... | |||||
When TNM is... | And grade is... | And HER2 status is... | And ER status is... | And PR status is... | Then the pathological prognostic stage group is... |
T1 N0 M0 T2 N0 M0 | Any | Negative | Positive | Any | IA |
NOTES:
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