End points | Overall | Number of additional risk factors on CHA2DS2-VASc score | |||||
1 (HF only) | 2 | 3 | 4 | 5 | ≥6 | ||
Patients without atrial fibrillation | |||||||
Patients, number (%) | 33,592 | 2366 (7.0) | 4503 (13.4) | 7462 (22.2) | 9183 (27.3) | 5958 (17.7) | 4120 (12.3) |
Ischemic stroke | |||||||
Events, number | 977 | 29 | 62 | 141 | 258 | 212 | 275 |
Person-years, number | 9,448,812 | 711,473 | 1,393,807 | 2,180,746 | 2,529,593 | 1,599,137 | 707,004 |
Incidence rate, % (95% CI) | 1.0 (1.0-1.1) | 0.4 (0.3-0.6) | 0.4 (0.3-0.6) | 0.6 (0.5-0.8) | 1.0 (0.9-1.2) | 1.3 (1.2-1.5) | 2.6 (2.4-3.0) |
Thromboembolism¶ | |||||||
Events, number | 3187 | 110 | 276 | 548 | 853 | 683 | 717 |
Person-years, number | 9,040,950 | 696,366 | 1,348,456 | 2,104,494 | 2,421,856 | 1,518,482 | 652,067 |
Incidence rate, % (95% CI) | 3.5 (3.4-3.6) | 1.6 (1.3-1.9) | 2.0 (1.8-2.3) | 2.6 (2.4-2.8) | 3.5 (3.3-3.8) | 4.5 (4.2-4.8) | 7.5 (7.0-8.1) |
Death | |||||||
Events, number | 6956 | 149 | 332 | 1256 | 2239 | 1596 | 1384 |
Person-years, number | 9,596,399 | 715,795 | 1,404,213 | 2,201,781 | 2,566,123 | 1,632,315 | 731,311 |
Incidence rate, % (95% CI) | 7.2 (7.1-7.4) | 2.1 (1.8-2.4) | 2.4 (2.1-2.6) | 5.7 (5.4-6.0) | 8.7 (8.4-9.1) | 9.8 (9.3-10.3) | 12.9 (12.2-13.6) |
Patients with atrial fibrillation | |||||||
Patients, number (%) | 9395 | 606 (6.5) | 931 (9.9) | 1752 (18.7) | 2571 (27.4) | 137 (20.6) | 1598 (17.0) |
Ischemic stroke | |||||||
Events, number | 318 | 8 | 11 | 32 | 82 | 80 | 105 |
Person-years, number | 1,592,497 | 55,019 | 110,265 | 294,757 | 477,528 | 365,633 | 180,083 |
Incidence rate, % (95% CI) | 2.0 (1.8-2.2) | 1.5 (0.7-2.9) | 1.0 (0.6-1.8) | 1.1 (0.8-1.5) | 1.7 (1.4-2.1) | 2.2 (1.8-2.7) | 3.6 (3.0-4.4) |
Thromboembolism¶ | |||||||
Events, number | 651 | 18 | 31 | 85 | 158 | 169 | 190 |
Person-years, number | 1,551,095 | 54,425 | 107,277 | 287,648 | 468,813 | 357,479 | 172,156 |
Incidence rate, % (95% CI) | 4.2 (3.9-4.5) | 3.3 (2.1-5.2) | 2.9 (2.0-4.1) | 3.0 (2.4-3.7) | 3.4 (2.9-3.9) | 4.7 (4.1-5.5) | 6.9 (6.0-8.0) |
Death | |||||||
Events, number | 2153 | 11 | 47 | 282 | 677 | 561 | 575 |
Person-years, number | 1,630,977 | 55,347 | 111,192 | 297,304 | 489,042 | 373,574 | 186,490 |
Incidence rate, % (95% CI) | 13.2 (12.7-13.8) | 2.0 (1.1-3.6) | 4.2 (3.2-5.6) | 9.5 (8.4-10.7) | 13.8 (12.8-14.9) | 15.0 (13.8-16.3) | 18.9 (17.4-20.5) |
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