Protocol step | Vaginal suppositories dose (mg) | Number of suppositories | Total dose | Time interval (minutes) |
1 | 0.05 | 1 | 0.05 | 20 |
2 | 0.05 | 2 | 0.1 | 20 |
3 | 0.5 | 1 | 0.5 | 20 |
4 | 0.5 | 2 | 1 | 20 |
5 | 5 | 1 | 5 | 20 |
6 | 5 | 2 | 10 | 20 |
7 | 50 | 1 | 50 | 20 |
8 | 50 | 2 | 100 | 20 |
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