Condition | Measured serum osmolality | Serum sodium by autoanalyzer | Serum sodium by direct ion-selective electrode |
Normal patient | Normal | Normal | Normal |
Hypotonic hyponatremia | Low | Low | Low |
Hyperglycemia or intravenous mannitol or immune globulin | High | Low | Low |
Absorbed surgical irrigants | Normal* | Low | Low |
Pseudohyponatremia due to hyperlipidemia or hyperproteinemia | Normal | Low | Normal |
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