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Cancer risk in the autoimmune rheumatic diseases reported in several meta-analyses

Cancer risk in the autoimmune rheumatic diseases reported in several meta-analyses
Disease Author (year) Pooled SIR or RR for all cancers Tumor types with increased risk
Rheumatoid arthritis Simon (2015)[1] 1.09 (1.06, 1.13) Lymphoma (Hodgkin, non-Hodgkin), lung, melanoma
Systemic lupus erythematosus Bernatsky (2013)[2] 1.14 (1.05, 1.23) Lymphoma (non-Hodgkin), lung, leukemia, thyroid
Systemic sclerosis (scleroderma) Onishi (2013)[3] 1.41 (1.18, 1.68) Lung, liver, hematologic, bladder
Myositis
  • Polymyositis
 Yang (2015)[4] 1.62 (1.19, 2.04) Lung, kidney, breast, lymphoma, bladder, endometrial, cervical, thyroid, brain
  • Dermatomyositis
 5.50 (4.31, 6.70) Ovary, breast, lung, colorectal, cervical, bladder, nasopharyngeal, esophagus, pancreas, kidney
Sjögren's disease Liang (2014)[5] 1.53 (1.17, 1.88) Non-Hodgkin lymphoma, thyroid
ANCA-associated vasculitis Shang (2015)[6] 1.74 (1.37, 2.21) Non-melanoma skin, leukemia, bladder, lymphoma, liver, lung
ANCA: antineutrophil cytoplasmic antibody; RR: risk ratio; SIR: standardized incidence ratio.
References:
  1. Simon TA, Thompson A, Gandhi KK, et al. Incidence of malignancy in adult patients with rheumatoid arthritis: A meta-analysis. Arthritis Res Ther 2015; 17:212.
  2. Bernatsky S, Ramsey-Goldman R, Labrecque J, et al. Cancer risk in systemic lupus: An updated international multi-centre cohort study. J Autoimmun 2013; 42:130.
  3. Onishi A, Sugiyama D, Kumagai S, Morinobu A. Cancer incidence in systemic sclerosis: Meta-analysis of population-based cohort studies. Arthritis Rheum 2013; 65:1913.
  4. Yang Z, Lin F, Qin B, et al. Polymyositis/dermatomyositis and malignancy risk: A metaanalysis study. J Rheumatol 2015; 42:282.
  5. Liang Y, Yang Z, Qin B, Zhong R. Primary Sjogren's syndrome and malignancy risk: A systematic review and meta-analysis. Ann Rheum Dis 2014; 73:1151.
  6. Shang W, Ning Y, Xu X, et al. Incidence of cancer in ANCA-associated vasculitis: A meta-analysis of observational studies. PLoS One 2015; 10:e0126016.

Reproduced from: Egiziano G, Bernatsky S, Shah AA. Cancer and autoimmunity: Harnessing longitudinal cohorts to probe the link. Best Pract Res Clin Rheumatol 2016; 30:53. Table used with the permission of Elsevier Inc. All rights reserved.

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