Antidepressant* | Dose (mg/day) |
Agomelatine (United States: Not available) | 53 |
Amitriptyline | 122 |
Bupropion | 349 |
Clomipramine | 116 |
Desipramine | 196 |
Dothiepin (United States: Not available) | 155 |
Doxepin | 140 |
Escitalopram | 18 |
Fluvoxamine | 143 |
Imipramine | 137 |
Lofepramine (United States: Not available) | 250 |
Maprotiline (United States: Not available) | 118 |
Mianserin (United States: Not available) | 101 |
Mirtazapine | 51 |
Moclobemide¶ (United States: Not available) | 575 |
Nefazodone | 535 |
Nortriptyline | 101 |
Paroxetine | 34 |
Reboxetine (United States: Not available) | 12 |
Sertraline | 99 |
Trazodone | 401 |
Venlafaxine | 149 |
The doses listed here are not recommended for initiating therapy. Rather, the doses provide a starting point for the purpose of comparing and switching different antidepressants during maintenance therapy for unipolar depression. Dose equivalences are only one of several factors to consider for targeting a dose range when switching antidepressants; refer to UpToDate topic text.
The estimated dose equivalence will generally require rounding to the nearest available product strength(s), which can be found in the drug-specific monographs included within UpToDate.MAOI: monoamine oxidase inhibitor.
* Dose equivalence for some antidepressants, such as citalopram and duloxetine, were not available. Citalopram is considered approximately one-half as potent as escitalopram; based on escitalopram equivalence data, citalopram 36 mg appears to be equivalent to fluoxetine 40 mg.
¶ Moclobemide is a reversible MAOI; switching to or from an MAOI requires specific precautionary measures. Refer to UpToDate text.Do you want to add Medilib to your home screen?